Teams

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Teams :

Teams

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Pathophysiology of Ion Transport

Team leaders : Laurent COUNILLON et Christophe DURANTON Our research aims at providing the highest-level scientific knowledge on the mechanisms, functions and pathophysiological implications of ion channels and transporters that control key biological parameters. As such our studies encompass a wide array of questions that range from basic cellular mechanisms to the regulation of complex physiological functions. We integrate information from datasets obtained mostly through our measurements on different models (cell lines, animal models, and from patients, thanks our strong links collaboration with clinicians, mostly from the University Hospital of Nice (CHU Nice) but also from national and international consortia.

Team 2: Osteoimmunology, niches and inflammation

Team leader: Claudine Blin Bone marrow is the site of bone remodeling and immune cell differentiation, as well as a major site for the maintenance of memory lymphocytes. Interactions between bone cells (osteoclasts, osteoblasts), immune cells and their progenitors are therefore permanent and fundamental. Dysregulation of these interactions is associated with many pathologies, including chronic inflammatory diseases frequently characterized by severe bone destruction. The projects we are developing are intended to dissect these interactions and to determine how they contribute to the maintenance of bone and immuno-hematological system homeostasis. They are conducted either in a physiological context, or in a context of chronic inflammation associated with bone defects (Crohn's disease, rheumatoid arthritis, osteoporosis, transplant rejection).