Team 2: Osteoimmunology, niches and inflammation
Team leader: Claudine Blin
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Team leader: Claudine Blin
Bone marrow is the site of bone remodeling and immune cell differentiation, as well as a major site for the maintenance of memory lymphocytes. Interactions between bone cells (osteoclasts, osteoblasts), immune cells and their progenitors are therefore permanent and fundamental. Dysregulation of these interactions is associated with many pathologies, including chronic inflammatory diseases frequently characterized by severe bone destruction.
The projects we are developing are intended to dissect these interactions and to determine how they contribute to the maintenance of bone and immuno-hematological system homeostasis. They are conducted either in a physiological context, or in a context of chronic inflammation associated with bone defects (Crohn's disease, rheumatoid arthritis, osteoporosis, transplant rejection).
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